PPARa and fatty acid oxidation mediate glucocorticoid resistance in chronic lymphocytic leukemia
نویسندگان
چکیده
Division of Molecular and Cellular Biology, Sunnybrook Research Institute, Toronto, ON, Canada; Department of Medical Biophysics, and Department of Immunology, University of Toronto, Toronto, ON, Canada; Transplant Research Division, Toronto General Hospital, Toronto, ON, Canada; Ontario Cancer Institute/Princess Margaret Hospital, Toronto, ON, Canada; Department of Medicine, University of Toronto, Toronto, ON, Canada; Max Planck Institute for Dynamics of Complex Technical Systems, Bioprocess Engineering Group, Magdeburg, Germany; and Sunnybrook Odette Cancer Center, Toronto, ON, Canada
منابع مشابه
PPARα and fatty acid oxidation mediate glucocorticoid resistance in chronic lymphocytic leukemia.
High-dose glucocorticoids (GCs) can be a useful treatment for aggressive forms of chronic lymphocytic leukemia (CLL). However, their mechanism of action is not well understood, and resistance to GCs is inevitable. In a minimal, serum-free culture system, the synthetic GC dexamethasone (DEX) was found to decrease the metabolic activity of CLL cells, indicated by down-regulation of pyruvate kinas...
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